Chemoreceptors in Respiratory Control

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The following animation will explain what effect this will have on the central chemoreceptors.

This is going to create a problem for John- he needs to be ventilating at an increased level to maintain his oxygen levels; but the hypocapnia is going to decrease his "drive to breathe". This decrease will cause his oxygen levels to fall - an obvious problem.

Respiratory Chemoreflex Pathway and Hypersensitization | Frontiers Research Topic

How is his brain going to reconcile these inputs? In other words - they are going to "accept" a PaCO 2 of 30 as normal.

How are the central chemoreceptors going to do this? Well, actually, they aren't Going back to that last animation, we see that because of the lower PaCO 2 in John's blood, not only is John's blood more basic, but his CSF is as well. After formation, the CSF flows through the foramen of Magendie and Luschka to the subarachnoid space, where it is absorbed by the arachnoid villi into the venous sinuses and carried away in the blood.


  • Control of ventilation - Wikipedia!
  • Introduction.
  • Peripheral Chemoreceptors.
  • Central chemoreceptors;

The spinal cord has similar villi that project into the veins in the area to allow the CSF in the spinal cord to be removed. This has occurred in both his plasma and his CSF.

Chemical Control of Breathing

You've already discussed the compensations that will serve to correct the arterial pH in response to this respiratory alkalosis - the good news is that very similar changes will occur in the CSF! The cells of the choroid plexus are also capable of creating hydrogen ion and bocarbonate from the CO 2 in the blood.

Unlike the situation near the central chemoreceptors where the carbonic anhydrase is located in the CSF , the cells of the choroid plexus contain the carbonic anhydrase and can then selectively pump either the hydrogen ion or the bicarbonate into the CSF. Bicarbonate is moved to the blood you have to get it out of the cells of the plexus to prevent the process from stopping.

Control of ventilation

The kidneys will get rid of it from there. This, predictably, leads to a respiratory acidosis as well as acidifying the CSF. Peripheral chemoreceptors are located in carotid and aortic bodies that have neuro-epithelial cells that contact with sensory nerve terminals.

About this book

They respond to changes in pO 2 , pCO 2 and pH. This causes an increase in initiation of dopamine, impulses to respiratory center via the glossopharyngeal nerves N IX and an increase in ventilation. Personal tools Talk Contributions Log in.


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